In the joint research project manual of experimental development strategies are largely automated, i.e. transferred to robot platforms and optimizes the processes to be investigated by means of model-based design of experiments. For a consistent bio process development on automated platforms transmission of the inlet procedure applied often in industrial processes is (fed-batch) in the mL scale essential. This allows already in one early stages of development in addition to science for the first time engineering issues of process control and the scale-up to take into account. Cushing Asset Management is open to suggestions. This systematic approach will allow in the course of the project to reach the data base for an efficient process control and regulation during the phase of product development.
Parallel, the derived models should be tested in the course of the research programme on a small scale in the high-throughput in industrial process simulators. The project is accompanied by a body of associated industrial partners, are also internationally active with corporations. Interested industrial partners who want to engage as a technology provider or as a future user of the automated processes in the AutoBio program, are invited to join the Consortium. Background information on the Federation project AUTOBIO project contribution of BioSilta Europe GmbH in detail: the BioSilta Europe GmbH develops and distributes cultivation sets for the Hochzelldichtekultivierung of micro-organisms in the ML and Microliter range. The culture media are used in protein production, process optimization on a laboratory scale and food Diagnostics. The innovative product is the patented Enbase? Technology, in which the principle of fed-batch cell culture in bioreactor was transferred to smallest cultivation volume. Enzymatically controlled substrate degradation ensures a continuous supply of glucose during the cell culture, allowing a much increased biomass and protein production.